The Wayans Brothers are back in a significant way.

Paramount and Miramax's revival of Scary Movie opened to $40 million domestic this weekend, with a projected $70 million worldwide total. For a pure comedy to reach that opening? It's the biggest comedy launch in years.

According to Deadline Hollywood's box office preview, this result signals that audiences want big-screen comedies. After years of streaming dominance and franchise fatigue, the Wayans Brothers demonstrated that nostalgia and comedy can drive box office returns.

Masters of the Universe is tracking for $50 million worldwide, while The Amazing Digital Circus is projected at $15 million-plus for its U.S. opening—evidence that the YouTube-to-screen pipeline is a growing commercial force.

Comedy remains a viable theatrical draw. With Scary Movie leading, Hollywood has demonstrated that audiences will pay to watch comedies in theatres.